1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 For animal use only. This dose may need to be repeated in 21 days. Grow Your Pharma Business Digitally. Required fields are marked with * Services & Products of Interest * Project Description . All Photos (1) Empirical Formula (Hill Notation): C . Piperazine is an antihelminthic drug that selectively blocks the neuromuscular cholinergic receptors of worms. Praziquantel: 5.1-11.4mg/kg orally, SC or IM . Repeat dose in 10 days : Anthelminthic: Piperazine citrate: 100mg/kg/day for 2 doses : 200mg/kg orally: 200mg/kg orally: Anthelminthic. When this is taken into account, the results of the present study support those of earlier workers i.e. Category. ChildrenDose is based on body weight and must be determined by your doctor. Vishal Laboratories - Offering Piperazine Adipate IP, Piperazine Adipate in Rajkot, Gujarat. Piperazine Adipate is an odorless white crystalline powder or solid, with a slightly acid taste. pH (0.2-0.01 molar aqueous solutions) 5.45. pH (5% solution) 5 - 6. Piperazine can be given orally by mouth in each bird, or added to the flock's water source. Used to treat ascarids and some nodular worms and pin worms. Login; Upload 'Piperazine adipate' presentation slideshows. Animals with known kidney pathology should be treated only . Piperazine readily absorbs water and carbon dioxide from the air. Create. 1. Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine was introduced to medicine as a solvent for uric acid. Inhibitor Targets. Piperazine is a medication used to treat roundworm and pinworm. Molecular Weight. Piperazine adipate inhibits oxaloacetate reduction by 26% . Piperazine adipate. June 13-16, 2022 Booth 1441. Piperazine Adipate exists as small alkaline deliquescent crystals with a saline taste. ChildrenDose is based on body weight and must be determined by your doctor. Sloan et al. Slightly acid taste. " ; the pH of a 10% aqueous solution of piperazine is 10.8-11.8. National Institutes of Health. Piperazine | C4H10N2 | CID 4837 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Piperazine Adipate is used as an anthelmintic agent. hydrate, citrate, adipate, phosphate, etc.). In between cycles, it is recommended to do an enema at night to remove pinworms from the rectum - for adults 4-5 glasses of water, children - 1-3 glasses of water with the addition 0,5 teaspoons of sodium bicarbonate in a glass of water. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Piperazine Adipate: Sigma-Aldrich: For experimental / research use only. However, the usual dose is 75 mg (piperazine hexahydrate) per kilogram (34 mg per pound) of body weight per day for two days in a row. Oxamniquine is an alternative to praziquan- tel for the treatment of schistosomiasis (p.138) due to Schisto-soma mansoni, although resistance has occurred, particularly in South America,1 . It has Molecular formula CC4H10N2,C6H10O4, Molecular weight 232.3g/mol. Repeat in 7-10 days. Powder: -20C for 3 years. All Photos (1) P1900000. References and Literature. Recent Presentations Content Topics Updated Contents Featured Contents. Used to treat cestodes: Prednisone [0001] Aceclidine is a muscarinic agonist with a quinuclidine ring (a tertiary nitrogen as part of a heterocyclic carbon ring) along with an acetyl ester bond to the heterocyclic ring two carbons away. Doses . Piperazine adipate oral suspension: For treating roundworm or pinworm infections: The recommended oral dose for Adult and children above 14 years is 1.8g orally for every 4 hours three times a day . Get latest price. PHYSICAL DESCRIPTION: Odorless white crystalline powder or solid. In Vitro. Piperazine is the only FDA approved dewormer for use in laying hens in the United States. It especially affects immature and sexually mature individuals of helminths of both sexes (roundworms and pinworms), causing muscle paralysis of these nematodes. If given by mouth: 50 mg/bird (if younger than 6 weeks of age), otherwise 100 mg/bird (if older than 6 weeks of age), or according to the manufacturer label. Novel oxadiazole derivatives of the formula (I), in which R, R, Y, X 1, X 2 and X 3 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and conditions such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, in general in all types of fibroses . Piperazine adipate: 200 mg/kg PO q24h 7 days, off 7 days, on 7 days 3: Rats/pinworms : 200-600 mg/kg PO q24h 7 days, off 7 days, on 7 days 3: Gerbils : 500 mg/kg PO q24h 66: Chinchillas : 0.5 mg/mL drinking water 21 days 3: Rats/pinworms : 3-5 mg/mL drinking water 7 days, off 7 days, on 7 days 66: Hamsters : 4-7 mg/mL drinking water . Kids can assign ready 5% solution. Ingredient UNII CAS InChI Key; Piperazine adipate: V7P5P122LB: 142-88-1: BVEGEKOBSPXUJS-UHFFFAOYSA-N: Piperazine citrate . Of the auxiliary substances in "Piperazine" there are potato or corn starch and . Appearance: Solid powder Purity: >98% (or refer to the Certificate of Analysis) Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. (NTP, 1992) The adult oral dose of 4 g of piperazine hydrate has been used extensively in the treatment of ascariasis. 8,562/ PIECE Get Latest Price. Piperazine-17 Medicated Caution (s) Although Piperazine is a drug with a wide margin of safety, occasionally an animal may show nausea, vomiting, or muscular tremors. Piperazine derivatives are known to have high antiserotonin potency, antimicrobial activity, and potential anticancer activity in humans. Antiparasitic. In some cases, particularly for aceclidine, stability in solution is . Contact. with piperazine (1:1) . CAS No. Praziquantel: 5-10mg/kg orally, SC or IM . Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Home Tools. Oral administration is the rule. Piperazine is a narrow-spectrum anthelmintic effective maily against gastrointestinal ascarids. Ahmedabad . HHS Vulnerability Disclosure. 1- (2-Methoxyphenyl)Piperazine Hydrobromide CAS 100939-96-6. Browse . List of Drug Master Files (DMF) of Piperazine Adipate Active Pharmaceutical Ingredient (API) submitted to the U.S. FDA. Dissolves slowly. The 'Hazard classification and labelling' section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation. National Library of Medicine. Piperazine Adipate is A white or almost white Crystalline Powder. Presentation Survey Quiz Lead-form E-Book. Original . Piperazine has a high therapeutic index with LD 50 values of more than 4000 mg/kg in mice for both the hexahydrate and adipate salts (Cross et al., 1954). Piperazine is a type of drug called an anthelmintic. It has no effect on any other species of worms, including tapeworms. Get here the data of piperazine adipate (cas no 142-88-1), piperazine adipate manufacturers, suppliers and exporters. Piperazine adipate. read more. Piperazine dihydrochloride contains 50 to 53% of piperazine base. dosage, form, labeller, route of administration, and marketing period. Department of Health and Human Services. Piperazine (diethylenediamine) adipate is an anthelmintic. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Treatment may need to be repeated in one week. Derivatives of piperazine are widely used in the pharmaceutical, biomedical and chemical fields. : HY-B2186 CAS No. 3mg/ml in drinking water orally: 200mg/kg orally for 7 days (for pinworm) Anthelminthic. The oral LD50 of piperazine adipate in mice is 11.4 g/kg. Piperazine . ADAPALENE Powder Get latest price ALBUTEROL SULPHATE Get latest price Acenocoumarol Powder Get latest price Aceclofenac Get latest price. May 17-19, 2022 Booth 1319. Policies. Quick Inquiry. Piperazine Adipate Pro Get powerful tools for managing your contents. Market Place. Schistosomiasis. Access now . Piperazine adipate is a potent broad spectrum anthelmintic. The corres-ponding figures for adipate and citrate are 37% and 35% respectively. Synonym: Piperazine adipate; NSC 74383; NSC-74383; NSC74383; IUPAC/Chemical Name: Hexanedioic acid, compd. For tablet dosage form: For common roundworms: Adults and teenagers3.5 grams (piperazine hexahydrate) per day for two days in a row. It causes the worms to become paralyzed, which forces them to detach from the intestinal wall and allows your cat's body to flush them out through normal excretory processes. Piperazine compounds as poultry ascaracides atmosphere.35 It is only slightly toxic to rats and mice; the LD50 of the pure compound administered orally is approximately 7.9 g per kg for rats, and 11.4 g per kg for mice.8 Absorption in the gut is slower than that of the hydrate or citrate.9,17 It is commercially available . PHARMA COMPASS . The tablets themselves are round, white, and are at risk of being split into halves. Cautions. Adults and childrenDose is based on body weight and must be determined by your doctor. PowerPoint Templates. Treatment needs to be repeated in 7-10 days since the drug does not kill the large roundworm eggs. Its holds from 98.0% to 101.0% Assay on dry basis. Manufacturer of Piperazine Derivatives - Piperazine Citrate, Piperazine Adipate offered by Adani Pharmachem Private Limited, Rajkot, Gujarat. (1954), Shumard and Eveleth (1955), Horton-Smith and Please Wait. National Library of Medicine. Product name : Piperazine adipate Catalog No. Log in . Applying Filters. : 142-88-1 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Each salt contains a different amount of piperazine "base": adipate 37%; chloride 48%; citrate 35%; phosphate 42%; the hexahydrate 44%, the sulphate 46%. If you compare the input cost increase, dry fodder cost has increased by more than 60-70%, green fodder by 40-50% and cattle feed price has increased by 20-22%. 1- (2-Methoxyphenyl)Piperazine Hydrobromide CAS 100939-96-6 CAS: 100939-96-6 Molecular Formula: C11H17BrN2O Quality Standard: pharm grade Packing: 25kg/fiber drum Mininmum Order: 25kg. The medicine is presented in pharmacies in two dosages - 200 mg or 500 mg of the active compound in one tablet. US EN. Effects of Punica granatum Fruit Dry Rind Powder and Piperazine Adipate against Ascaridia galli. PubChem . Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. European Pharmacopoeia (EP) Reference Standard . Adults and teenagers3.5 grams (piperazine hexahydrate) per day for two days in a row. The main component of this drug is called piperazine adipate, so you can find a similar drug on sale, called that way. Doses expressed in terms of the amount of piperazine base are: for swine 110 mg/kg bw and for poultry 32 mg/kg bw . 142-88-1) is an alternative treatment for ascariasis caused by roundworms and Oxyuriasis by pinworms.With the Molecular Formula of C 10 H 20 N 2 O 4,it is especially useful in the treatment of partial intestinal obstruction caused by Acaris worms, which is commonly seen . While . Pure piperazine itself is unstable in water and to ensure the required stability in human and veterinary medicines various salts are used (e.g. National Center for Biotechnology Information. Piperazine can be given orally by mouth in each bird, or added to the flock's water source. Although many piperazine derivatives occur naturally, piperazine . FOIA. Missed dose If you miss a dose of piperazine, take it as soon as possible. Formula C10H20N2O4 Molecular Weight 232.277 Exact Mass 232.142 LogP 0.5528 PSA 98.66 Synonyms PIPERAZINE . These results suggest that a 50 mg/kg dose of C. crista seed powder, its equivalent methanolic extract and piperazine (200 mg/kg) are equieffective in treating the ascarid infection of poultry. The posology depends on animal species, and also on the salt used. Collection of Piperazine adipate slideshows. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in . WARNINGS: Do not worm a kitten less than six weeks of age. 232.28. Post Enquiry. The range of quality piperazine adipate offered by Indian manufacturing companies are high in demand. Jigs Chemical Limited. Effect of parbendazole and piperazine . This is equivalent to 32 mg piperazine per kg bodyweight Cattle, horses, pigs : 2,2 g Piper Dewormer wsp per 10 kg bodyweight, equivalent to 110 mg of piperazine base per kg bodyweight. Dosage: Calulate dose rate of 4mL per 5kg bodyweight. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Repeat dose in 10 days. Other muscarinic agonists with a quinuclidine ring include but are not limited to cevimeline, talsaclidine, and WAY-132983. Catalog NO. Molecular Formula. In the last one year, MRP increase has been only 9% in all varieties except full cream where it is 12% to 13% vis--vis price paid to the farmers have increased by 15%. It is only effective against the adult large roundworm. However, the usual dose is 65 mg (piperazine hexahydrate) per kilogram (29.5 mg per pound) of body weight per day for seven days in a row. piperazine adipate treatment piperazine adipate compositions Prior art date 1953-10-21 Legal status (The legal status is an assumption and is not a legal conclusion. Melting point 256-257C. Treatment may need to be repeated in one week. However, the usual dose is 75 mg (piperazine hexahydrate) per kilogram (34 mg per pound) of body weight per day for two days in a row . Anthelminthic . Compounds of the formula II: wherein R1 and R2 are independently H, F or CH3; or R1 forms an ethynyl bond and R2 is H or C3-C6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF3, OMe or halo; R3 is C1-C3 alkyl or C3-C6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or . Piperazine for Cats Overview. Browse. Send Email 08048968611 79% Response Rate A single dose should not exceed 20 mg/kg. Piperazine adipate: .5g/kg/day for 2 doses: 500 micrograms/kg/day. Dosage depends on the geographical origin of the in-fection and total doses range from 15 mg/kg as a single dose to 60 mg/kg given over 2 to 3 days. Access drug product information from over 10 global regions. It is readily absorbed, but has a highly variable half-life. Solubility Information. Get contact details and address| ID: 1235259673 The amount of anthelmintic base in active piperazine salts is respectively, for adipate 37%, chloride 48%, citrate 35%, dihydrochloride 50 to 53%, hexahydrate 44%, phosphate 42% and sulphate 46%. The crude C. crista powder appears to be potent and safer than its methanol extract on the basis of the side effects observed. Hazard classification and labelling. Original Data : FDA Website It is used moderately in swine and poultry (mainly as feed additives) and horses, rather scarcely in pets and only marginally in ruminants. Piperazine adipate European Pharmacopoeia (EP) Reference Standard; CAS Number: 142-88-1; find -P1900000 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. given as a water soluble powder or as solutions mostly mixed into water or animal feed. : 142-88-1 | CAS NO. PharmaCompass' API Reference Price for Piperazine Adipate determined using sample data obtained from Indian Trade (Import/Export). Sodium Citrate Dehydrate Powder, Povidone Iodine Powder, Piperazine Adipate Powder, Potassium Magnesium Citrate Powder, Oxyclozanide Powder, etc. Piperazine Adipate (450mg) uses PACKAGE CONTENTS: Blister of 12 capsules ACTIVE INGREDIENT: Each capsule contains 140 mg Piperazine Adipate (450mg) (as Citrate) PURPOSE: For the removal of large roundworms, Toxocara canis and Toxacaris leonina , in cats. 0 Call Us +918071858930886 Send Inquiry In solvent: -80C for 2 years. Used to treat ascarids and some nodular worms and pin worms. : 142-88-1 | Brand: BOC Sciences. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs . General Description. Such side effects are usually associated with over-dosage. Piperazine Adipate(CAS NO. C10H20N2O4. The posology depends on the animal species, and also on the salt used. Find list of most trusted exporters of Piperazine Adipate Oral Powder in India with contact details including address, email and phone number. Anthelminthic . Repeat dose in 10 days. Description. When taken into the body the drug is partly oxidized and partly eliminated . Piperazine is freely soluble in water and ethylene glycol, but insoluble in diethyl ether. Piperazine Adipate is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Access now. Estimated API Price per kg in USD for Piperazine Adipate obtained from the import, export data from major ports of India . Online. Piperazine adipate is an insoluble salt.18 It is stable to heat and 494. In cats, adverse effects occur within 24 hours after a toxic dose is ingested. 142-88-1 Piperazine adipate Assay:99% Appearance:White fine powder Package:according to the clients requirement Storage:Store in dry dark and ventilated place Transportation:Transportation by express, air, sea; port mainly to Qingdao / Tianjin / Shanghai, or according to customer needs to send different ports and aviation.Application:It is an important raw material. This type of drug functions by targeting the nervous systems of the parasites that are attached to your cat's intestinal wall. Acefylline Piperazine By Jigs Chemical Limited . This dosage is based on layers with a bodyweight of 2,5 kg and a water uptake of 210 ml per animal per day. Drugs . Treatment needs to be repeated in 7-10 days since the drug does not kill the large . Website Search Google Search PIPERAZINE ADIPATE V7P5P122LB US Previously Marketed Source: PIPERAZINE CITRATE by ALPHARMA US PHARMS (1982) Source URL: . National Institutes of Health. Difluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid productionDifluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid production . X. PHARMA COMPASS. Piperazine adipate >98.0%: Maypro Industries: Piperazine Adipate: Santa Cruz Biotechnology: For experimental / research use only. Expired - Lifetime Application number US463317A Inventor Forrest James Petrow Vladimir Current Assignee (The listed . January 2007; Saudi Journal of Biological Sciences 14(2):185-192; Authors: Areej O. Bakraibah . Overdosage - Acute massive overdosage can lead to paralysis and death, but the drug is generally considered to have a wide margin of safety. CAS number:18428-63-2 (18833-13-1)Certificate: ISO CERTIFICATE, FACTORY GMP, Properties : Synonym 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7h-purine- More. hexahydrate, phosphate and adipate) are given as water soluble powder or as solutions mostly mixed into water or animal feed. The amount of anthelmintic base in active piperazine salts is 35% for the citrate and 50 to 53% for the dihydrochloride. The piperazine salts are used for the treatment of ascarids in dogs, cats, horses, pigs and poultry.Piperazine Kyron is a white crystalline powder consisting of I 00% piperazine adipate (=37% piperazine base).Piperazine acts by altering muscular polarisation in susceptible nematodes, thereby paralysing the worm and allowing it to be passed out with the faeces. Presentation Creator Create stunning presentation online in just 3 steps. Get contact details, email, phone and address of companies manufacturing and supplying Piperazine Adipate Oral Powder along with details of Piperazine Adipate Oral Powder importers and buyers. Piperazine adipate; Quality Upgrade Quality Assurance Flexible Package Options. Therefore, recommended dosage should be followed carefully. Piperazine adipate -25 gram Pharmacological properties : Fenbendazole (5-phenylthio-2-benzimidazole carbamate) has a wide range of nematodicidal, cestodocidal action, is active against adult forms and larvae of nematodes of the gastrointestinal tract and lungs and certain types of trematodes and cestodes. H2O: 14.29 mg/mL (61.52 mM), Need ultrasonic ( < 1 mg/ml refers to the product slightly soluble or insoluble ) Citations. It is a weak base with two pK b of 5.35 and 9.73 at 25 C.

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